Adresse
Inselspital
Freiburgstrasse 18
3010 Bern
Switzerland
Neurocenter Bern
Neurocenter at University Hospital Bern Inselspital represents an internationally renowned nucleus of innovation in stroke medicine, collaborating in several international multicentre trials and leading in innovative stroke research strategies. Our group at Neurocenter Bern pioneered the first reports on safety and efficacy of acute recanalization therapies including intravenous thrombolysis in patients with recent DOAC ingestion. Further analyses and international collaborations led by our group expanded those findings allowing more liberal decision to offer IVT in patients with recent DOAC intake based on plasma level measurements and reversal with idarucizumab – a specific antidote to the DOAC dabigatran. Considering the expertise and promising results derived from observational data, this randomized-controlled clinical trial is the next step in the field of endovascular stroke treatment, demonstrating benefits of IVT in acute ischemic stroke patients with recent DOAC intake.
DO-IT Core Team
PD Dr. med. Thomas Meinel, PhD
Principal-Investigator
Department of Neurology
University Hospital Bern Inselspital
Freiburgstrasse 18
CH-3010 Bern
Prof. Dr. med. Luciana Catanese
Principal-Investigator
Hamilton Health Sciences
McMaster University
237 Barton Street East
Hamilton, Ontario, L8L 2X2 Canada
Prof. Dr. med. Urs Fischer
Principle-Investigator
Department of Neurology
University Hospital Bern Inselspital
Freiburgstrasse 18
CH-3010 Bern
Prof. Dr. med. Aristeidis Katsanos
Principal-Investigator
Hamilton Health Sciences
McMaster University
237 Barton Street East
Hamilton, Ontario, L8L 2X2 Canada
Prof. Dr. med. David Seiffge
Principle-Investigator
Department of Neurology
University Hospital Bern Inselspital
Freiburgstrasse 18
CH-3010 Bern
Prof. Dr. med. Ashkan Shoamesh
Principal-Investigator
Hamilton Health Sciences
McMaster University
237 Barton Street East
Hamilton, Ontario, L8L 2X2 Canada
Amanda Taylor, BSc
Canadian Trial Coordination: Australia, Canada, UK
Population Health Research Institute
amanda.taylor@phri.ca
Lukas Bütikofer, PhD
Trial Statistician
Clinical Trial Unit
University of Bern
Mittelstrasse 43
CH-3012 Bern
Stefanie Abend, BSc
Trial Management
Neuro Clinical Trial Unit
University Hospital Bern Inselspital
Freiburgstrasse 18
CH-3010 Bern
stefanie.abend@insel.ch
Phone: +41 31 632 67 80
Freschta Zipser-Mohammadzada, PhD
Trial Management
Neuro Clinical Trial Unit
University Hospital Bern Inselspital
Freiburgstrasse 18
CH-3010 Bern
freschta.zipser-mohammadzada@insel.ch
+41 31 63 2 60 83
Nerea Fernandez Trigo, PhD
Trial Management
Neuro Clinical Trial Unit
University Hospital Bern Inselspital
Freiburgstrasse 18
CH-3010 Bern
nerea.fernandeztrigo@insel.ch
+41 31 632 23 52